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exclusive The Pituitary 4th Ed 2017


The Pituitary 4th Ed 2017
نقرتين لعرض الصورة في صفحة مستقلة
Description
The Pituitary, Fourth Edition, continues the tradition of a cogent blend of basic science and clinical medicine which has been the successful hallmark of prior editions. This comprehensive text is devoted to the pathogenesis, diagnosis, and treatment of pituitary disorders. The new edition has been extensively revised to reflect new knowledge derived from advances in molecular and cell biology, biochemistry, diagnostics, and therapeutics as they apply to the pituitary gland.

The wide spectrum of clinical disorders emanating from dysfunction of the master gland is described in detail by experts in the field. Fundamental mechanisms underlying disease pathogenesis are presented to provide the reader with an in-depth understanding of mechanisms subserving both normal and disordered pituitary hormone secretion and action. View more >

Key Features
Brings together pituitary experts from all areas of research and practice who take readers all the way from bench research, to genomic and proteomic analysis, clinical analysis, and new therapeutic approaches to pituitary disorders
Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of issues related to normal and diseased pituitary function
Provides a common language for endocrinologists, neurosurgeons, OB/GYNs, and endocrine researchers to discuss how the pituitary gland and hormones affect each major organ system
Readership
Researchers, practitioners, and graduate students, in endocrinology and researchers of endocrine diseases across biomedical disciplines, as well as those working with endocrinologists such as neurosurgeons and OB/GYNs

Table of Contents
Dedication
List of Contributors
Preface
Section I: Hypothalamic–Pituitary Function
Chapter 1. Pituitary Development
Abstract
Introduction
The Pituitary Gland
Formation of Rathke’s Pouch
Glandular or Endocrine Gland Development
Signals Controlling Pituitary Development
Cell Differentiation
Tissue Architecture and Cell Networks
Pituitary Cell Cycle Control
Progenitors and Stem Cells
Corticotrophs
Melanotrophs
Gonadotrophs
Somatotrophs
Lactotroph Differentiation
Thyrotrophs
Perspectives
Acknowledgments
References
Chapter 2. Hypothalamic Regulation of Anterior Pituitary Function
Abstract
Introduction
Anatomy and Histology of the Hypothalamic–Pituitary Unit
Cellular Composition of the Anterior Pituitary
Hypothalamic Factors Regulating Pituitary Function
Hypothalamic Prolactin Regulators
Summary
References
Chapter 3. Adrenocorticotrophin
Abstract
Introduction
Corticotroph Biology
Proopiomelanocortin Gene
Regulation of the HPA Axis
Effects of Secreted POMC-Derived Peptides in Physiology and Disease
ACTH
Measurement Assays for ACTH (RIA, IRMA, LC/MS, etc.)
References
Chapter 4. Growth Hormone
Abstract
Introduction
Growth Hormone Gene Structure
GH Synthesis
Hypothalamic Hormones
GH Action
GH and Metabolism
GH and Reproduction
GH/IGF-1 and Cardiovascular Function
GH Effects on Renal Function
Tests of GH Secretion
Clinical Use of GH
GH Therapy in Adults
References
Chapter 5. Prolactin
Abstract
Introduction
Historical Overview
Cell of Origin
Prolactin Gene
Hormone Biosynthesis
Hormone Secretion: Biochemistry
Neuroendocrine Regulation
Prolactin Action
Acknowledgments
References
Chapter 6. Thyroid-Stimulating Hormone
Abstract
Introduction
Ontogeny of Thyrotroph Cells
TSH Subunit Genes
TSH Biosynthesis
Regulation of TSH Biosynthesis
TSH Secretion
Regulation of TSH Secretion
Action of TSH
TSH Measurements
Disorders of TSH Production
References
Chapter 7. Gonadotrophin Hormones
Abstract
Introduction
Development, Embryology, and Histology
Biochemical Structure and Molecular Biology of LH and FSH
Ontogeny and Physiology of LH and FSH Secretion
Biologic Functions of LH and FSH
Assay Systems for the Measurement of Gonadotrophins
Hypothalamic Regulation of LH and FSH
Feedback Regulation of LH and FSH Secretion
Molecular Biology of LH and FSH Subunit Genes
Diagnostic Tests
Clinical Disorders Affecting the Gonadotroph
Acquired Hypogonadotrophic Disorders
Hypergonadotrophic Disorders: Excessive or Nonphysiologic Secretion of Gonadotrophins
Treatment of Hypogonadotrophic Disorders
Acknowledgments
References
Chapter 8. The Posterior Pituitary
Abstract
Introduction
Structure of the Neurohypophysis: Anatomy and Electrophysiology of Vasopressin-Producing Cells
The Vasopressin and Oxytocin Genes
Chemistry, Processing, and Metabolism of AVP
Control of AVP Secretion
Vasopressin Receptors and Antagonists
Cellular Actions of Vasopressin
Quantitating Renal Water Excretion
Clinical Characteristics of Diabetes Insipidus Disorders
Investigation of a Patient With Polyuria
Radioimmunoassay of AVP, Copeptin, and Other Laboratory Determinations
Syndrome of Inappropriate Secretion of the Antidiuretic Hormone (SIADH)
Signs, Symptoms, and Treatment of Hyponatremia
Acknowledgments
References
Section II: Hypothalamic–Pituitary Disorders
Chapter 9. The Hypothalamus
Abstract
Introduction
Anatomy
Hypothalamic Physiology
Pathophysiology of Hypothalamic syndromes
Clinical Features of Hypothalamic Syndromes
Specific Hypothalamic Disorders
Traumatic brain injury
References
Chapter 10. Anterior Pituitary Failure
Abstract
Introduction
Mortality
Etiology
Clinical Manifestations
Diagnostic Testing
Treatment of Hypopituitarism
References
Chapter 11. Pituitary Dysfunction in Systemic Disorders
Abstract
Introduction
Systemic Disorders Directly Affecting the Pituitary Gland
Autoimmune
Amyloidosis
Infectious Diseases
Iron Overload
Snakebite
Metastatic Cancer (see also chapter: Nonpituitary Sellar Masses)
Genetic Multiglandular Tumoral Syndromes (see also chapter: Genetics of Pituitary Tumor Syndromes)
Other Stalk and Pituitary Lesions (see also chapter: Nonpituitary Sellar Masses)
Changes in Pituitary Morphology and Function with Aging
General Effects of Systemic Illness on Pituitary Function
Pituitary Alterations Associated With Specific Systemic Disorders
Acknowledgments
References
Chapter 12. Drugs and Pituitary Function
Abstract
Introduction
Opiates and Opiate Antagonists
Amphetamines and Methylphenidate
Caffeine
Benzodiazepines
Antidepressants
Lithium
Antipsychotic Drugs
Other Dopamine Antagonists
Dopamine Agonists
Cholinergic Agonists and Antagonists
Antihypertensives
Antihistamines
Cancer Therapies
Estrogens
Androgens
Antiandrogens
Glucocorticoids
Endocrine-Disrupting Chemicals
Miscellaneous Drugs
Alcohol
Smoking
Cocaine
Acknowledgments
References
Chapter 13. The Pituitary Gland in Pregnancy
Abstract
Introduction
Normal Pituitary during Pregnancy
Pituitary Tumors and Pregnancy
Nontumoral Pituitary Disturbances Related to Pregnancy
Conclusions
References
Chapter 14. Psychiatric Disease in Hypothalamic–Pituitary Disorders
Abstract
Introduction
Psychiatric Diseases in Hypothalamic–Pituitary Disorders
Hormone Excess Syndrome and Psychiatric Disorders
Rare Diseases of the Hypothalamus/Pituitary Gland and Psychiatric Disorders
Diagnosing Psychiatric Disorders in Hypothalamlic–Pituitary Diseases
Therapy of Psychiatric Disorders in Hypothalamic–Pituitary Disease
Acknowledgments
References
Section III: Pituitary Tumors
Chapter 15. Acromegaly
Abstract
Introduction
Pathogenesis
Genetic Syndromes
Clinical Features of Acromegaly
Diagnosis
Treatment of Acromegaly
Selective Estrogen Receptor Modulators
Choice of Therapy
References
Chapter 16. Prolactinoma
Abstract
Introduction
Classification
Epidemiology and Natural History of Prolactinomas
Pathogenesis
Clinical Manifestations
Diagnosis
Treatment
Special Situations
Acknowledgment
References
Chapter 17. Cushing Disease
Abstract
Introduction
Pathophysiology
Epidemiology
Chronic ACTH and Proopiomelanocortin (POMC) Peptide Oversecretion by the Pituitary
Pathology of the Adrenal in Cushing Disease
Other Causes of Cushing’s Syndrome
Clinical Features
Diagnosis of Cushing Disease
Cushing Disease in Children
Cushing Disease in Pregnant Women
Long-Term Outcome of Cushing Disease
Diagnostic Approach
Imaging Techniques
Pitfalls in Diagnosis
Treatment
Pituitary Surgery and Radiation
Medical Treatments
Overall Approach for Treatment
Future Directions
Acknowledgments
References
Chapter 18. Thyrotrophin-Secreting Pituitary Tumors
Abstract
Introduction
Pathogenesis
Pathology
Clinical Features
Diagnosis
Differential Diagnosis
Treatment
Criteria of Cure and Follow-Up
Conclusions
References
Chapter 19. Nonfunctioning and Gonadotrophin-Secreting Adenomas
Abstract
Introduction
Epidemiology
Pathology
Etiology
Clinical Features
Assessment
Differential Diagnosis
Treatment
Gonadotrophinomas
References
Chapter 20. Atypical Pituitary Adenomas
Abstract
Introduction
Current WHO Definition of Atypical Pituitary Adenomas
Controversies Regarding the Nature and Diagnosis of Atypical Pituitary Adenomas
Genetics and Molecular Basis of Atypical Pituitary Adenomas
Clinical Characteristics and the Functional Status of Atypical Pituitary Adenomas
Prognostic Factors in Atypical Pituitary Adenomas
Surgical Management of Atypical Pituitary Adenomas
Medical Management of Atypical Pituitary Adenomas
Radiation Therapy/Stereotactic Radiosurgery
Future Avenues
Conclusions
References
Chapter 21. Genetics of Pituitary Tumor Syndromes
Abstract
Introduction
Syndromic Conditions Associated With Pituitary Adenomas
Genetic Forms of Isolated Pituitary Adenomas
Genetic Testing Overview
References
Chapter 22. Nonpituitary Sellar Masses
Abstract
Introduction
Clinical Diagnosis
Imaging Diagnosis
Morphological Diagnosis
Specific Lesions
Conclusion
References
Section IV: Pituitary Procedures
Chapter 23. Pituitary Imaging
Abstract
Introduction
History of Pituitary Imaging
Plain Films and Tomograms
Angiography
Computed Tomography
MR: Technique and Anatomy
Pituitary Size and Shape
Microadenomas
Macroadenomas
Posterior Pituitary
Other Intrasellar/Suprasellar Masses
Empty Sella
References
Chapter 24. Pituitary Surgery
Abstract
Historical Overview
Diagnostic Evaluation
Surgical and FunctionalAnatomy
Surgical Techniques
Complications
Further Treatment
Pituitary Tumors
Evolving Technologies
References
Index

About the Editor
Shlomo Melmed
Dr. Melmed co-edits Endocrinology: Basic and Clinical Principles, is the Neuroendocrine Section Editor for DeGroot and Jameson's Textbook of Endocrinology, and Williams Textbook of Endocrinology; and is pituitary section author for Harrison's Textbook of Medicine. In addition to being the Editor-in-Chief of Pituitary, he is on the editorial board of Journal of Clinical Investigation and past Editor-in-Chief of Endocrinology.

Details
No. of pages : 715
Language: English
size: 21.3 mb

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